亚洲星,亚洲星娱乐

挊彂柤/妛弍榑暥

Publications

Peer-reviewed primary publications

1. Saeki N, Saito A, Sugaya Y, Mitsuhiro Amemiya M, Sasaki H. Indirect down-regulation of tumor suppressive let-7 family microRNAs by LMO1 in neuroblastoma. Cancer Genomics Proteomics 15: 413-420, 2018. (Corresponding author)

2. Saeki N, Saito A, Sugaya Y, Mitsuhiro Amemiya M, Ono H, Komatsuzaki R, Yanagihara K, Sasaki H. Chromatin immunoprecipitation and DNA sequencing identified a LIMS1/ILK pathway regulated by LMO1 in neuroblastoma. Cancer Genomics Proteomics 15: 165-174, 2018. (Corresponding author)

3. Ono H, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen is expressed in normal and malignant human brain tissues. Oncol Lett 15(3): 3081-3084, 2018. (Corresponding author)

4. Saeki N, Komatsuzaki R, Chiwaki F, Yanagihara K, Sasaki H. A GSDMB enhancer-driven HSV thymidine kinase expressing vector for controlling occult peritoneal dissemination of gastric cancer cells. BMC Cancer 15: 439, 2015. (Corresponding author)

5. Saeki N, Ono H, Sakamoto H, Yoshida T. Down-regulation of immune-related genes by PSCA in gallbladder cancer cells implanted into mice. Anticancer Res 35(5): 2619-2625, 2015. (Corresponding author)

6. Saeki N, Ono H, Yanagihara K, Aoyagi K, Sasaki H, Sakamoto H, Yoshida T. rs2294008 T, a risk allele for gastric and gallbladder cancers, suppresses a PSCA promoter by recruiting a transcription factor YY1. Genes Cells 20(5): 382-391, 2015. (Corresponding author)

7. Ono H, Chihara D, Chiwaki F, Yanagihara K, Sasaki H, Sakamoto H, Tanaka H, Yoshida T, Saeki N, Matsuo K. Missense allele of a single nucleotide polymorphism rs2294008 attenuated anti-tumor effects of prostate stem cell antigen (PSCA) in gallbladder cancer cells. J Carcinog12:4, 2013. (Corresponding author)

8. Ono H, Yanagihara K, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen gene is expressed in islets of pancreas. Anat Cell Biol 45(3):149-154, 2012. (Corresponding author)

9. Ono H, Hiraoka N, Lee YS, Woo SM, Lee WJ, Choi IJ, Saito S, Yanagihara K, Kanai Y, Ohnami S, Chiwaki F, Sasaki H, Sakamoto H, Yoshida T, Saeki N. Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis. Genes Chromosomes Cancer 51(1):30-41, 2012.

10. Saeki N, Saito A, Choi IJ, Matsuo K, Ohnami S, Totsuka H, Chiku S, Kuchiba A, Lee YS, Yoon KA, Kook MC, Park SR, Kim YW, Tanaka H, Tajima K, Hirose H, Tanioka F, Matsuno Y, Sugimura H, Kato S, Nakamura T, Nishina T, Yasui W, Aoyagi K, Sasaki H, Yanagihara K, Katai H, Shimoda T, Yoshida T, Nakamura Y, Hirohashi S, Sakamoto H. A functional SNP in MUC1, at chromosome 1q22, determines susceptibility to diffuse-type gastric cancer. Gastroenterology 140(3): 892-902, 2011.

11. Wang K, Diskin SJ, Zhang H, Attiyeh EF, Winter C, Hou C, Schnepp RW, Diamond M, Bosse K, Mayes PA, Glessner J, Kim C, Frackelton E, Garris M, Wang Q, Glaberson W, Chiavacci R, Nguyen L, Jagannathan J, Saeki N, Sasaki H, Grant SF, Iolascon A, Mosse YP, Cole KA, Li H, Devoto M, McGrady PW, London WB, Capasso M, Rahman N, Hakonarson H, Maris JM. Integrative genomics identifies LMO1 as a neuroblastoma oncogene. Nature 469(7329): 216-220, 2011.

12. Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang ZF, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Guarrera S, Polidoro S, Chang SC, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet 41(9): 991-995, 2009.

13. Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T, Sasaki H. Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancers 48(3): 261-271, 2009.

14. Ohta H, Aoyagi K, Fukaya M, Danjoh I, Isohata N, Saeki N, Taniguchi H, Sakamoto H, Shimoda T, Tani T, Yoshida T, Sasaki H. Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer 100(2): 389-398, 2009.?

15. Sakamoto H^#, Yoshimura K^#, Saeki N^#, Katai H, Shimoda T, Matsuno Y, Saito D, Sugimura H, Tanioka F, Kato S, Matsukura N, Matsuda N, Nakamura T, Hyodo I, Nishina T, Yasui W, Hirose H, Hayashi M, Toshiro E, Ohnami S, Sekine A, Sato Y, Totsuka H, Ando M, Takemura R, Takahashi Y, Ohdaira M, Aoki K, Honmyo I, Chiku S, Aoyagi K, Sasaki H, Ohnami S, Yanagihara K, Yoon KA, Kook MC, Lee YS, Park SR, Kim CG, Choi IJ, Yoshida T, Nakamura Y, Hirohashi S. Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.丂Nat Genet 40(6): 730-740, 2008. ^#equal contribution

16. Saeki N, Kim DH, Usui T, Aoyagi K, Tatsuta T, Aoki K, Yanagihara K, Tamura M, Mizushima H, Sakamoto H, Ogawa K, Ohki M, Shiroishi T, Yoshida T, Sasaki H. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Oncogene 26(45): 6488-6498, 2007.

17. Usui T, Aoyagi K, Saeki N, Nakanishi Y, Kanai Y, Ohki M, Ogawa K, Yoshida T, Sasaki H. Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells. Int J Oncol 29(4): 779-784, 2006.

18. Fukaya M, Isohata N, Ohta H, Aoyagi K, Ochiya T, Saeki N, Yanagihara K, Nakanishi Y, Taniguchi H, Sakamoto H, Shimoda T, Nimura Y, Yoshida T, Sasaki H. Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. Gastroenterology 131(1): 14-29, 2006.

19. Chuma M, Saeki N, Yamamoto Y, Ohta T, Asaka M, Hirohashi S, Sakamoto M. Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis. Keio J Med 53(2): 90-97, 2004.?

20. Saeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T. Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome 11(9): 718-724, 2000.

Review articles

<English>

1. Saeki N, Sakamoto H, Yoshida T. Mucin 1 gene (MUC1) and gastric-cancer susceptibility. Int J Mol Sci 15(5): 7958-7973, 2014 (Corresponding author) 丂

2. Ono H, Saeki N. Five gastric cancer-susceptibility loci identified by genome-wide association studies. J Gastroint Dig Sys S12, 2013. doi: 10.4172/2161-069X.S12-015 (Corresponding author)

3. Saeki N, Ono H, Sakamoto H, Yoshida T. Genetic factors related to gastric-cancer susceptibility identified using a genomewide association study. Cancer Sci 104(1): 1-8, 2013. (Corresponding author)

4. Saeki N, Sasaki H . LMO1 (LIM domain only 1 (rhombotin 1)). Atlas Genet Cytogenet Oncol Haematol, August 2011. URL : http://AtlasGeneticsOncology.org/Genes/LMO1ID33ch11p15.html

(Corresponding author)

5. Saeki N, Gu J, Yoshida T, Wu X. Prostate Stem Cell Antigen: A Jekyll and Hyde Molecule? Clin Cancer Res 16(14): 3533-3538, 2010.

6. Yoshida T, Ono H, Kuchiba A, Saeki N, Sakamoto H. Genome-wide germline analyses on cancer susceptibility and GeMDBJ database: Gastric cancer as an example. Cancer Sci 101(7): 1582-1589, 2010.

7. Saeki N, Sasaki H. GSDMA (gasdermin A). Atlas Genet Cytogenet Oncol Haematol, November 2010. URL : http://AtlasGeneticsOncology.org/Genes/GSDMAID45650ch17q21.html

<Japanese>

1. 彫栰峅宐丄嵅攲愰媣丄嶁杮桾旤丄媑揷婸旻. 敪偑傫慺場偲偟偰偺PSCA堚揱巕. 嵶朎43姫13崋517-520, 2011.

2. 彫栰峅宐丄嵅攲愰媣丄戝楺弐暯丄嶁杮桾旤丄媑揷婸旻. 堚揱巕懡宆偼徚壔婍偑傫偺敪徢偵偳偺傛偆偵塭嬁偡傞偺偐. 暘巕徚壔婍昦8姫3崋238-239, 2011.

3. 嵅攲愰媣丄嶁杮桾旤丄媑揷婸旻. 堓娻偺僎僲儉栐梾揑娭楢夝愅偲幘姵僎僲儉僨乕僞儀乕僗. 椪徢徚壔婍撪壢24姫4崋426?432, 2009.

4. 嵅攲愰媣丄嶁杮桾旤丄媑揷婸旻. 堓娻娭楢堚揱巕偺慡僎僲儉娭楢夝愅. 嵟怴堛妛64姫4崋887-893, 2009.

5. 嵅攲愰媣丄嶁杮桾旤丄媑揷婸旻. 堓偑傫偺僎僲儉栐梾揑娭楢夝愅偲GeMDBJ僨乕僞儀乕僗. 擔杮椪徢67姫6崋1227-1232, 2009.

Books

1. Saeki N, Ono H. Prostate stem cell antigen and pancreatic cancer. In: Endocrine disease. (iConcept Press Ltd. ed.), pp.1-24, iConcept Press Ltd., Hong Kong, 2014.

妛夛敪昞昞戣

Presentations

International conferences

1. Hiromi Sakamoto, Norihisa Saeki, Hidemi Itoh, Keitro Matsuo, Hidetaka Yamada, Haruhiko Sugimura,Hitoshi Ichikawa, Hiroki Sasaki, Teruhiko Yoshida. Towards the Genetics and Genomics of Diffuse Gastric Cancer. The 4th JCA-AACR Special Joint Conference乮The Latest Advances in Gastric Cancer Research: From Basic Science to Therapeutics), Urayasu-shi, Chiba, December 16-18, 2013

2. Saeki N, Choi IJ, Lee YS, Yoon KA, Kook MC, Park SR, Kim YW, Ono H, Sakamoto H, Matsuo K, Yoshida T. Gastric-cancer susceptibility genes identified through collaboration between Japanese and Korean research groups. The 17th Japan-Korea Cancer Research Workshop, Busan Korea, Nov 30 - Dec 2 2012. (poster)

3. Norihisa Saeki, Hiroe Ono, Hiromi Sakamoto, Teruhiko Yoshida. Current Status in the Study of PSCA function at National Cancer Center Research Institute, Japan. The 4th meeting of the International Consortium of Bladder Cancer. Houston, Texas, December 2010.

Domestic conferences

1. 嵅攲愰媣丄嵵摗憦丄悰扟桬庽丄塉媨岝岹丄嵅乆栘攷屓. 恄宱夎庮偵偍偄偰丄偑傫懀恑揮幨挷愡場巕LMO1偼偑傫梷惂揑let-7僼傽儈儕乕microRNA偺敪尰傪梷惂偟偰偄傞.丂戞41夞擔杮暘巕惗暔妛夛擭夛. 墶昹 2018擭11寧 (億僗僞乕敪昞)

2. 崅嫶揘巎丄斞捤旤桳丄楅栘廏榓丄嵅攲愰媣丄楅栘岾抝丄拞懞惓旻丄屲廫楅愳榓恖丄嬥惉弐.  3D攟梴偼鋁憻娻嵶朎偺PSCA敪尰傪懀恑偡傞 戞39夞擔杮暘巕惗暔妛夛擭夛. 墶昹 2016擭11寧 (億僗僞乕敪昞)

3. 嵅攲愰媣. 恄宱夎庮偵偍偄偰揮幨挷愡場巕LMO1偑惂屼偡傞暘巕宱楬. 戞119夞擔杮彫帣壢妛夛妛弍廤夛. 嶥杫 2016擭5寧(岥墘敪昞)

4. 嵅攲愰媣丄嵵摗憦丄悰扟桬庽丄塉媨岝岹丄彫栰峅宐丄彫徏嶈棟奊丄嵅乆栘攷屓.丂ChIP-Seq傪梡偄偨偑傫懀恑揮幨挷愡場巕LMO1偺惂屼昗揑堚揱巕摨掕偵傛傞怴偨側恄宱夎庮帯椕昗揑暘巕宱楬偺扵嶕.丂戞38夞擔杮暘巕惗暔妛夛擭夛. 恄屗 2015擭12寧 (億僗僞乕敪昞)

5. 嵅攲愰媣丄嵵摗憦丄彫栰峅宐丄彫徏嶈棟奊丄嵅乆栘攷屓.丂 偑傫懀恑揮幨挷愡場巕LMO1偺昗揑堚揱巕扵嶕偵傛傝摨掕偝傟偨LIMS1/ILK暘巕宱楬偼恄宱夎庮偺怴婯帯椕昗揑偱偁傞. 戞74夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2015擭10寧 (岥墘敪昞)

6. 彫栰峅宐丄惵桍堦旻丄嵅乆栘攷屓丄桍尨屲媑丄嶁杮桾旤丂媑揷婸旻丄嵅攲愰媣.丂 SNPrs2294008偺T傾儗儖偼揮幨場巕YY1傪夘偟偰丄堓偑傫梷惂婡擻傪帩偮PSCA堚揱巕偺敪尰傪梷惂偡傞. 戞74夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2015擭10寧 (億僗僞乕敪昞)

7. 彫徏嶈棟奊丄嵅攲愰媣丄愮榚巎巕丄桍尨屲媑丄嵅乆栘攷屓. HSV僠儈僕儞僉僫乕僛堚揱巕傪梡偄偨堓偑傫暊枌揮堏惂屼偨傔偺堚揱巕帯椕儀僋僞乕偺奐敪. 戞74夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2015擭10寧 (億僗僞乕敪昞)

8. 嵅攲愰媣. 揮幨場巕LMO1偺昗揑堚揱巕摨掕偵傛傞怴偨側恄宱夎庮帯椕昗揑暘巕宱楬偺扵嶕. 戞118夞擔杮彫帣壢妛夛妛弍廤夛. 戝嶃 2015擭4寧(岥墘敪昞)

9. 徏壓椓曘丄 崅嫶揘巎丄徏塱壚梍巕丄楅栘廏榓丄崱堜婱梇丄幣揷怶夘丄嵅攲愰媣丄揷熀孿復丄壀栰塰擵丄拞懞惓旻.丂Numb 偵傛傞SNP 埶懚揑側慜棫態姴嵶朎峈尨PSCA揮幨挷愡婡峔偺夝愅. 戞135夞擔杮栻妛夛擭夛. 恄屗 2015擭3寧(億僗僞乕敪昞)

10. 嵅攲愰媣丄彫栰峅宐丄惵桍堦旻丄嵅乆栘攷屓丄桍尨屲媑丄嶁杮桾旤丄媑揷婸旻. 堦墫婎懡宆rs2294008偺T傾儗儖偼揮幨場巕YY1傪夘偟偰丄偑傫梷惂婡擻傪帩偮PSCA堚揱巕偺敪尰傪梷惂偟丄堓偑傫堈滊姵惈偺尨場偲側傞.丂戞37夞擔杮暘巕惗暔妛夛擭夛. 墶昹 2014擭11寧 (億僗僞乕敪昞)

11. 彫栰峅宐丄嶁杮桾旤丄媑揷婸旻丄嵅攲愰媣. Prostate stem cell antigen (PSCA)偺惓忢擼慻怐媦傃擼庮釃偱偺敪尰. 戞73夞擔杮娻妛夛妛弍憤夛. 墶昹 2014擭9寧 (億僗僞乕敪昞)

12. 彫栰峅宐丄嶁杮桾旤丄媑揷婸旻丄嵅攲愰媣. 鋁娗偑傫偱敪尰偑桿摫偝傟傞PSCA堚揱巕偼惓忢鋁憻偺儔儞僎儖僴儞僗搰偱敪尰偟偰偄傞. 戞72夞擔杮娻妛夛妛弍憤夛. 墶昹 2013擭10寧 (億僗僞乕敪昞)

13. 彫栰峅宐丄愮尨戝丄愮榚巎巕丄嵅乆栘攷屓丄嶁杮桾旤丄媑揷婸旻丄徏旜宐懢榊丄嵅攲愰媣.? 堓偑傫丒銷泖偑傫堈滊姵惈娭楢堚揱巕PSCA忋偺儈僗僙儞僗SNP偼抇偺偆偑傫嵶朎偵偍偄偰PSCA偺偑傫梷惂婡擻傪尭庛偝偣傞. 戞71夞擔杮娻妛夛妛弍憤夛. 嶥杫 2012擭9寧 (億僗僞乕敪昞)

14. 媑揷婸旻丄嵅攲愰媣丄嵵摗憦丄 徏旜宐懢榊丄嵅乆栘攷屓丄戝楺悷巕丄彫栰峅宐丄嶁杮桾旤丄曅堜嬒. 堓偑傫偺僎僲儉栐梾揑娭楢夝愅.戞70夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2011擭10寧(僔儞億僕僂儉)

15. 嶁杮桾旤丄嵅攲愰媣丄嵵摗憦 徏旜宐懢榊丄嵅乆栘攷屓丄戝楺悷巕丄彫栰峅宐丄曅堜嬒丄悮懞弔旻丄媑揷婸旻. 堓偑傫偺僎僲儉栐梾揑堚揱慺場偺扵嶕. 戞70夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2011擭10寧(僔儞億僕僂儉)

16. 彫栰峅宐丄暯壀怢夘丄嬥堜栱塰丄嵅乆栘攷屓丄嶁杮桾旤丄媑揷婸旻丄嵅攲愰媣. 慡僎僲儉栐梾揑娭楢夝愅乮GWAS乯偵傛傝摨掕偝傟偨堓偑傫堈滊姵惈娭楢堚揱巕PSCA偺婡擻夝愅. 暯惉23 擭搙暥晹壢妛徣壢妛尋媶旓曗彆嬥怴妛弍椞堟尋媶亀偑傫尋媶暘栰偺摿惈摍傪摜傑偊偨巟墖妶摦亁暯惉23 擭搙偑傫庒庤尋媶幰儚乕僋僔儑僢僾. 澍壢 2011擭8寧(岥墘敪昞)

17. 嵅攲愰媣丄嵵摗憦 徏旜宐懢榊丄曅堜嬒丄戝楺悷巕丄岥塇暥丄嵅乆栘攷屓丄悮懞弔旻丄拞懞桽曘丄淎嫶愢梇丄媑揷婸旻丄嶁杮桾旤. 慡僎僲儉娭楢夝愅偵傛傝摨掕偝傟偨傃傑傫宆堓偑傫堈滊姵惈娭楢愼怓懱椞堟1q22. 戞69夞擔杮娻妛夛妛弍憤夛. 戝嶃 2010擭9寧(岥墘敪昞)

18. 彫栰峅宐丄暯壀怢夘丄嬥堜栱塰丄嶁杮桾旤丄媑揷婸旻丄嵅攲愰媣.? 堓忋旂嵶朎偵偍偄偰偑傫梷惂堚揱巕揑摿挜傪帩偮PSCA堚揱巕偺抇擷偑傫偱偺敪尰梷惂. 戞69夞擔杮娻妛夛妛弍憤夛. 戝嶃 2010擭9寧(億僗僞乕敪昞)

19. 戝楺悷巕丄嵅攲愰媣丄嶁杮桾旤丄媑揷婸旻. 枹暘壔宆堓態偑傫偺堈滊姵惈偲憡娭偡傞PSCA堚揱巕懡宆. 戞54夞擔杮恖椶堚揱妛夛. 搶嫗 2009擭9寧(岥墘敪昞)

20. 嵅攲愰媣丄嶁杮桾旤丄媑懞岞梇丄壓揷拤榓丄曅堜嬒丄戝楺悷巕丄惵桍堦旻丄嵅乆栘攷屓丄淎嫶愢梇丄媑揷婸旻.? Diffuse宆堓偑傫堈滊姵惈偲憡娭偡傞PSCA堚揱巕偺SNPs偵偮偄偰偺婡擻夝愅. 戞67夞擔杮娻妛夛妛弍憤夛. 柤屆壆 2008擭10寧 (岥墘敪昞)

21. 嶁杮桾旤丄媑懞岞梇丄嵅攲愰媣丄曅堜嬒丄壓揷拤榓丄戝楺悷巕丄娭崻復攷丄Yoon K-A丄Choi IJ丄拞懞桽曘丄淎嫶愢梇丄媑揷婸旻. Diffuse宆堓偑傫偺堈滊姵惈偲憡娭偡傞PSCA堚揱巕懡宆. 戞67夞擔杮娻妛夛妛弍憤夛. 柤屆壆? 2008擭10寧 (岥墘敪昞)

22. 嬥払峗丄嵅乆栘攷屓丄揷绮抭壚巕丄惣奯旤抭巕丄嵅攲愰媣丄妬尨揘榊丄帥揷夒徍. 堚揱巕憹暆偵敽偆敪尰堎忢偲儊僠儖壔. 戞102夞擔杮奜壢妛夛掕婜妛弍廤夛. 嫗搒2002擭4寧丂乮億僗僞乕敪昞乯